M.D. Brown, B.S. Generowicz, S. Dijkhuizen, S.K.E. Koekkoek, C. Strydis, J.G. Bosch, P. Arvanitis, G. Springeling, G.J.T. Leus, C.I. De Zeeuw, P. Kruizinga
@article{Brown2024,
title = {Four-dimensional computational ultrasound imaging of brain hemodynamics},
author = {M.D. Brown and B.S. Generowicz and S. Dijkhuizen and S.K.E. Koekkoek and C. Strydis and J.G. Bosch and P. Arvanitis and G. Springeling and G.J.T. Leus and C.I. De Zeeuw and P. Kruizinga},
doi = {10.1126/sciadv.adk79},
year = {2024},
date = {2024-01-17},
journal = {Scientific Advances},
volume = {10},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
S. Soloukey, E. Collée, L. Verhoef, D.D. Satoer, C.M.F. Dirven, E.M. Bos, J.W. Schouten, B.S. Generowicz, F. Mastik, C.I. De Zeeuw, S.K.E. Koekkoek, A.J.P.E. Vincent, M. Smits, P. Kruizinga
@article{Soloukey2023,
title = {Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries: A proof-of-concept study},
author = {S. Soloukey and E. Collée and L. Verhoef and D.D. Satoer and C.M.F. Dirven and E.M. Bos and J.W. Schouten and B.S. Generowicz and F. Mastik and C.I. De Zeeuw and S.K.E. Koekkoek and A.J.P.E. Vincent and M. Smits and P. Kruizinga},
url = {https://www.sciencedirect.com/science/article/pii/S1053811923005864?via%3Dihub},
doi = {10.1016/j.neuroimage.2023.120435},
year = {2023},
date = {2023-12-01},
journal = {NeuroImage},
volume = {283},
keywords = {Image-guided Neurosurgery, Whole brain functional imaging},
pubstate = {published},
tppubtype = {article}
}
@article{S2032,
title = {Functional imaging of the exposed brain},
author = {Soloukey S and Arnaud V.J.P.E. and Smits M. and De Zeeuw C. I. and Koekkoek S. K. E. and Clemens D. M. F., Kruizinga P.},
doi = {10.3389/fnins.2023.1087912},
year = {2023},
date = {2023-02-09},
journal = {Frontiers in Neuroscience},
volume = {17},
keywords = {Image-guided Neurosurgery, Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
@article{S2022,
title = { High-resolution micro-Doppler imaging during neurosurgical resection of an arteriovenous malformation: illustrative case},
author = {Soloukey S and Verhoef L and Jan van Doormaal P and Generowicz BS and Dirven CMF and De Zeeuw CI and Koekkoek SKE and Kruizinga P and Vincent AJPE and Schouten, JW },
doi = {10.3171/CASE22177},
year = {2022},
date = {2022-11-07},
journal = {Journal of Neurosurgery },
volume = {4},
number = {19},
keywords = {Image-guided Neurosurgery},
pubstate = {published},
tppubtype = {article}
}
Soloukey S, Verhoef L, Mastik F, Generowicz B S, Bos E M, Harhangi B S, Collée K E, Satoer D D, Smits M, Dirven C M F, De Zeeuw C I, Koekkoek S K E, Vincent A J P E, Kruizinga P
@article{S2021,
title = {Fully integrating functional Ultrasound (fUS) into the onco-neurosurgical operating room: Towards a new real-time, high-resolution image-guided resection tool with multimodal potential },
author = {Soloukey S and Verhoef L and Mastik F and Generowicz B S and Bos E M and Harhangi B S and Collée K E and Satoer D D and Smits M and Dirven C M F and De Zeeuw C I and Koekkoek S K E and Vincent A J P E and Kruizinga P },
doi = {10.1093/neuonc/noab180.091},
year = {2021},
date = {2021-09-09},
journal = { Neuro-Oncology},
volume = {23},
keywords = {Image-guided Neurosurgery},
pubstate = {published},
tppubtype = {article}
}
Soloukey S., Vincent A.J.P.E., Satoer D. D., Mastik F., Smits M., Dirven C. M. F., Strydis C., van der Steen A. F. W., Bosch J. G., De Zeeuw C. I., Koekkoek S .K. E., Kruizinga P.
@article{S.2020b,
title = {NIMG-19. USING FUNCTIONAL ULTRASOUND (FUS) TO MAP BRAIN FUNCTIONALITY AND TUMOR VASCULATURE WITH MICROMETER-MILLISECOND PRECISION },
author = { Soloukey S. and Vincent A.J.P.E. and Satoer D. D. and Mastik F. and Smits M. and Dirven C. M. F. and Strydis C. and van der Steen A. F. W. and Bosch J. G. and De Zeeuw C. I. and Koekkoek S .K. E. and Kruizinga P. },
doi = {10.1093/neuonc/noaa215.632},
year = {2020},
date = {2020-11-02},
journal = {Neuro-Oncology},
volume = {22},
keywords = {Image-guided Neurosurgery},
pubstate = {published},
tppubtype = {article}
}
Soloukey S., Vincent A. J. P. E., Satoer D. D., Mastik D. D., Smits
M., Dirven C. M. F., Strydis C., Bosch J. G., van der Steen A. F. W., De Zeeuw C. I., Koekkoek S. K. E. and
Kruizinga P.
@article{S.2020,
title = {Functional Ultrasound (fUS) During Awake Brain Surgery: The Clinical Potential of Intra-Operative Functional and Vascular Brain Mapping},
author = { Soloukey S. and Vincent A. J. P. E. and Satoer D. D. and Mastik D. D. and Smits
M. and Dirven C. M. F. and Strydis C. and Bosch J. G. and van der Steen A. F. W. and De Zeeuw C. I. and Koekkoek S. K. E. and
Kruizinga P.},
doi = {10.3389/fnins.2019.01384},
issn = {1662-453X},
year = {2020},
date = {2020-01-09},
journal = {Frontiers in Neuroscience},
volume = {13},
pages = {1384},
abstract = {Background and Purpose: Oncological neurosurgery relies heavily on making continuous, intra-operative tumor-brain delineations based on image-guidance. Limitations of currently available imaging techniques call for the development of real-time image-guided resection tools, which allow for reliable functional and anatomical information in an intra-operative setting. Functional ultrasound (fUS), is a new mobile neuro-imaging tool with unprecedented spatiotemporal resolution, which allows for the detection of small changes in blood dynamics that reflect changes in metabolic activity of activated neurons through neurovascular coupling. We have applied fUS during conventional awake brain surgery to determine its clinical potential for both intra-operative functional and vascular brain mapping, with the ultimate aim of achieving maximum safe tumor resection.
Methods: During awake brain surgery, fUS was used to image tumor vasculature and task-evoked brain activation with electrocortical stimulation mapping (ESM) as a gold standard. For functional imaging, patients were presented with motor, language or visual tasks, while the probe was placed over (ESM-defined) functional brain areas. For tumor vascular imaging, tumor tissue (pre-resection) and tumor resection cavity (post-resection) were imaged by moving the hand-held probe along a continuous trajectory over the regions of interest.
Results: A total of 10 patients were included, with predominantly intra-parenchymal frontal and temporal lobe tumors of both low and higher histopathological grades. fUS was able to detect (ESM-defined) functional areas deep inside the brain for a range of functional tasks including language processing. Brain tissue could be imaged at a spatial and temporal resolution of 300 μm and 1.5–2.0 ms respectively, revealing real-time tumor-specific, and healthy vascular characteristics.
Conclusion: The current study presents the potential of applying fUS during awake brain surgery. We illustrate the relevance of fUS for awake brain surgery based on its ability to capture both task-evoked functional cortical responses as well as differences in vascular characteristics between tumor and healthy tissue. As current neurosurgical practice is still pre-dominantly leaning on inherently limited pre-operative imaging techniques for tumor resection-guidance, fUS enters the scene as a promising alternative that is both anatomically and physiologically informative.},
keywords = {Image-guided Neurosurgery},
pubstate = {published},
tppubtype = {article}
}
Background and Purpose: Oncological neurosurgery relies heavily on making continuous, intra-operative tumor-brain delineations based on image-guidance. Limitations of currently available imaging techniques call for the development of real-time image-guided resection tools, which allow for reliable functional and anatomical information in an intra-operative setting. Functional ultrasound (fUS), is a new mobile neuro-imaging tool with unprecedented spatiotemporal resolution, which allows for the detection of small changes in blood dynamics that reflect changes in metabolic activity of activated neurons through neurovascular coupling. We have applied fUS during conventional awake brain surgery to determine its clinical potential for both intra-operative functional and vascular brain mapping, with the ultimate aim of achieving maximum safe tumor resection.
Methods: During awake brain surgery, fUS was used to image tumor vasculature and task-evoked brain activation with electrocortical stimulation mapping (ESM) as a gold standard. For functional imaging, patients were presented with motor, language or visual tasks, while the probe was placed over (ESM-defined) functional brain areas. For tumor vascular imaging, tumor tissue (pre-resection) and tumor resection cavity (post-resection) were imaged by moving the hand-held probe along a continuous trajectory over the regions of interest.
Results: A total of 10 patients were included, with predominantly intra-parenchymal frontal and temporal lobe tumors of both low and higher histopathological grades. fUS was able to detect (ESM-defined) functional areas deep inside the brain for a range of functional tasks including language processing. Brain tissue could be imaged at a spatial and temporal resolution of 300 μm and 1.5–2.0 ms respectively, revealing real-time tumor-specific, and healthy vascular characteristics.
Conclusion: The current study presents the potential of applying fUS during awake brain surgery. We illustrate the relevance of fUS for awake brain surgery based on its ability to capture both task-evoked functional cortical responses as well as differences in vascular characteristics between tumor and healthy tissue. As current neurosurgical practice is still pre-dominantly leaning on inherently limited pre-operative imaging techniques for tumor resection-guidance, fUS enters the scene as a promising alternative that is both anatomically and physiologically informative.
@conference{S.2019,
title = {Towards High-Resolution functional Ultrasound (fUS) Imaging of the Murine Spinal Cord},
author = {Soloukey S. and Harhangi B.S. and Generowicz, B. S. and Slenter J.P.H. and de Zeeuw, C. I. and Kruizinga P. and Koekkoek, S. K. E.},
doi = {10.1109/ULTSYM.2019.8926243},
isbn = {978-1-7281-4596-9},
year = {2019},
date = {2019-10-06},
booktitle = { International Ultrasonics Symposium (IUS)},
organization = {IEEE},
abstract = {While functional Ultrasound (fUS) is taking flight as a new high-resolution imaging tool for the brain, its application for spinal cord imaging has been mostly neglected so far. This, while the spinal cord plays an essential role in some of the questions currently asked in neuroscience. The current paper is the first to attempt to apply fUS to the mouse spinal cord, using an electrical epidural stimulation paradigm relevant to the current clinical questions being asked in e.g. the realm of spinal cord injury. We demonstrate the power of high-resolution vascular imaging of the murine spinal cord using both 2D and 3D-images and discuss potential applications of this newly available and unprecedented level of detailed microvascular information. In addition, we discuss one of the major problems facing the success of fUS-imaging for the (murine) spinal cord in particular: motion artefacts due to physiological and stimulation-evoked changes in breathing. Lastly, we discuss our vision on the necessary future steps which can facilitate successful fUS-imaging of the murine spinal cord.},
keywords = {Whole brain functional imaging},
pubstate = {published},
tppubtype = {conference}
}
While functional Ultrasound (fUS) is taking flight as a new high-resolution imaging tool for the brain, its application for spinal cord imaging has been mostly neglected so far. This, while the spinal cord plays an essential role in some of the questions currently asked in neuroscience. The current paper is the first to attempt to apply fUS to the mouse spinal cord, using an electrical epidural stimulation paradigm relevant to the current clinical questions being asked in e.g. the realm of spinal cord injury. We demonstrate the power of high-resolution vascular imaging of the murine spinal cord using both 2D and 3D-images and discuss potential applications of this newly available and unprecedented level of detailed microvascular information. In addition, we discuss one of the major problems facing the success of fUS-imaging for the (murine) spinal cord in particular: motion artefacts due to physiological and stimulation-evoked changes in breathing. Lastly, we discuss our vision on the necessary future steps which can facilitate successful fUS-imaging of the murine spinal cord.
S. Soloukey Tbalvandany, A.J.P.E. Vincent, D.D. Satoer, F. Mastik, M. Smits, C.M.F. Dirven, C. Strydis, A.F.W. van der Steen, J.G. Bosch, C.I. De Zeeuw, S.K.E. Koekkoek, P. Kruizinga
@article{Tbalvandany2019,
title = {Functional ultrasound (FUS) during awake craniotomy tumor removal: Revolutionizing intra-operative functional brain and tumor mapping},
author = {S. Soloukey Tbalvandany and A.J.P.E. Vincent and D.D. Satoer and F. Mastik and M. Smits and C.M.F. Dirven and C. Strydis and A.F.W. van der Steen and J.G. Bosch and C.I. De Zeeuw and S.K.E. Koekkoek and P. Kruizinga},
doi = {10.1159/000501568},
year = {2019},
date = {2019-07-01},
journal = {Stereotactic Functional Neurosurgery },
volume = {97},
keywords = {Image-guided Neurosurgery},
pubstate = {published},
tppubtype = {article}
}
@conference{Generowicz2018,
title = {Efficient and flexible spatiotemporal clutter filtering of high frame rate images using subspace tracking},
author = {B.S. Generowicz and G. Leus and S.S. Tbalvandanv and W.S. Van Hoogstraten and C. Strydis and J.G. Bosch and ... and P. Kruizinga},
doi = {10.1109/ULTSYM.2018.8579775 },
year = {2018},
date = {2018-10-01},
pages = {206-212},
publisher = { In 2018 IEEE International Ultrasonics Symposium (IUS) },
keywords = {Whole brain functional imaging},
pubstate = {published},
tppubtype = {conference}
}
@article{Rau2018,
title = {3D functional ultrasound imaging of pigeons},
author = {R. Rau and P. Kruizinga and F. Mastik, M. Belau and M. de Jong and J. G. Bosch and ... and G. Maret },
url = {https://www.sciencedirect.com/science/article/abs/pii/S1053811918307122},
doi = {10.1016/j.neuroimage.2018.08.014},
year = {2018},
date = {2018-10-01},
journal = {NeuroImage},
volume = {183},
pages = {469-477},
keywords = {Whole brain functional imaging},
pubstate = {published},
tppubtype = {article}
}
@conference{Koekkoek2018,
title = {High frequency functional ultrasound in mice},
author = {Koekkoek, S. K. E. and Tbalvandany, S. S. and Generowicz, B. S. and van Hoogstraten, W. S. and de Oude, N. L. and Boele, H. J. and ... and de Zeeuw, C. I.},
doi = {10.1109/ULTSYM.2018.8579865 },
year = {2018},
date = {2018-10-01},
pages = {1-4},
publisher = {In 2018 IEEE International Ultrasonics Symposium (IUS)},
keywords = {Whole brain functional imaging},
pubstate = {published},
tppubtype = {conference}
}
@conference{vanderP.2018,
title = {Joint Optimization of Coding Mask and Scan Positions for Compressive Single Sensor Imaging},
author = {van der Meulen P. and Kruizinga P. and Bosch J. and G. and Leus, G.},
doi = {10.1109/ULTSYM.2018.8579728},
year = {2018},
date = {2018-10-01},
publisher = {In 2018 IEEE International Ultrasonics Symposium},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {conference}
}
@article{Kang2018,
title = {A Reconfigurable Ultrasound Transceiver ASIC With 24x40 Elements for 3-D Carotid Artery Imaging},
author = {Kang E. and Ding, Q. and Shabanimotlagh M. and Kruizinga P. and Chang Z. Y. and Noothout E. and ... and Pertijs M. A. },
doi = { 10.1109/JSSC.2018.2820156},
year = {2018},
date = {2018-07-01},
journal = {IEEE Journal of Solid-State Circuits},
volume = {53},
number = {7},
pages = {2065-2075},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
@article{Renaud2018,
title = {In vivo ultrasound imaging of the bone cortex.},
author = {Renaud G. and Kruizinga P. and Cassereau D. and Laugier, P.},
doi = {10.1088/1361-6560/aac784},
year = {2018},
date = {2018-06-12},
journal = {Physics in Medicine & Biology},
volume = {63},
number = {12},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
@article{Janjic2018,
title = {Structured ultrasound microscopy},
author = {Janjic J. and Kruizinga P. and Van Der Meulen P. and Springeling G. and Mastik F. and Leus G. and ... and van Soest G. },
doi = {10.1063/1.5026863},
year = {2018},
date = {2018-04-01},
journal = {Applied Physics Letters},
volume = {112},
number = {25},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
@article{Kruizinga2017,
title = {Compressive 3D ultrasound imaging using a single sensor},
author = {Kruizinga P. and van der Meulen P. and Fedjajevs A. and Mastik F. and Springeling G. and de Jong N. and ... and Leus G.},
doi = {10.1126/sciadv.1701423 },
year = {2017},
date = {2017-12-08},
journal = {Science advances},
volume = {3},
number = {12},
keywords = {Next-generation ultrasound technology},
pubstate = {published},
tppubtype = {article}
}
